Moustapha Kassem

Bone marrow skeletal (stromal, mesenchymal) stem cells: from transplantation to in vivo targeting

Professor of Endocrinology, University Hospital of Odense, Director at the Stem Cell Research Laboratory, University of Southern Denmark, Professor of Stem Cell Biology, University of Copenhagen

Moustapha Kassem
10/11 2021
12:15-13:15, DIAS Auditorium (V24-501a-0)
Lecture

Bone marrow skeletal (mesenchymal) stem cells (MSC) are used in regenerative medicine to enhance tissue regeneration. However, cell transplantation faces major obstacle related to cell survival and integration into injured tissues.

One of the aims of my research program is to target MSC in vivo in order to enhance their proliferation and differentiation into bone forming osteoblastic cells for bone tissue regeneration.

In my presentation I will provide a short description of the biology of skeletal (mesenchymal) stem cells as relevant for regenerative medicine. I will present some recent data from my lab where we aimed at identifying novel secreted factors that we have been studying as molecular regulators for osteoblast differentiation and in vivo bone formation and that can be targeted to enhance bone formation. We have studies these secreted factors in vitro and in vivo and their clinical relevance in preclinical animal models.

ABOUT

Dr. Moustapha Kassem is a regular speaker at national and international conferences of bone biology and stem cells that include the Endocrine Society, ASBMR, and European Calcified Tissue Society. He is currently associate Editor of two journals: Bone and Aging Cell.  Dr. Moustapha Kassem has authored/co-authored 321 original manuscripts and invited reviews/book chapters. in 2012 he was awarded the prestigious Marie and August Krogh research award from the Danish Medical Association.

Dr. Moustapha Kassem has been studying osteoporosis cell biology and skeletal stem cell biology with an emphasis on the introduction of stem cell-based therapies in the clinic. He has multiple scientific achievements to his name including describing a novel method for the isolation of bone marrow skeletal stem cells (which later became known as stromal or mesenchymal stem cells (MSC)) from human bone marrow aspirates in 1991 that has become standard in the field.  Since then, he has characterized several model systems for studying the biology of MSCs that are being used by several international investigators.


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