Anti-virulence therapy: a future strategy for combating pathogenic bacteria?
Due to the rapid increase in antibiotic resistance, alternatives to classical antibiotics are receiving increasing attention, such as drugs that intervene with bacterial virulence. In my research group, we use the foodborne human pathogen Listeria monocytogenes as model organism for gaining new insights into bacterial pathogenesis. In this lecture, I will present some of our recent findings on how this bacterium controls the expression of virulence factors to cause disease. Furthermore, I will discuss how these findings inspired us to explore a novel strategy for combating pathogenic bacteria by selective inhibition of a virulence regulator.
About Birgitte Kallipolitis
Birgitte Kallipolitis obtained her Ph.D. in Molecular Biology in 1997 from the University of Southern Denmark. She was a postdoctoral fellow at the University of Copenhagen and a visiting scientist at UCC, Ireland. In 2001, she returned to the University of Southern Denmark as an Assistant Professor, and she became an Associate Professor in 2005. She was appointed Professor of Molecular Microbiology in 2017. The Kallipolitis-group has key competences in molecular studies of RNA and protein-based gene regulatory systems in Gram-positive bacteria. The group manages a fully equipped biosafety level 2 lab at the Department of Biochemistry and Molecular Biology, including facilities for infection studies in cultured cell lines and the model host C. elegans.
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Due to COVID-19 restrictions, this lecture may be held online and/or with limited participation.