The management of colorectal cancer meets many challenges most of which are due to the lack of knowledge about the factors that cause and drive the disease. Colorectal cancer has been linked to genetic mutations, inflammation, diet, and gut microbiota. How these factors crosstalk with one another to induce and drive disease, however, remains unclear. The goal of our research group is to dissect the molecular mechanisms through which gut microbiota and diet interact with host genetics to induce colorectal cancer. Better understanding of the impact of these factors on the intestinal physiology will shed light on the complex etiology of colorectal cancer. Our ultimate goal is to develop new approaches for manipulation of the gut microbiota by specific diets that provide control on the disease progression.